In this way, we managed to promote a device which created a safe environment for the drivers. Solution As safety was one of the primary concerns of Exploride, we created a heads up display as a smart solution for people to handle while driving, a solution which permitted them to communicate or view information without any distraction. The roughly 600 cops, spread out at precinct and PSAs across the city, will be reassigned into other posts, including the detective bureau and neighborhood police, the city's top cop said.
On behalf of my radiation oncology partner, Dr. Arjun Sahgal, I am pleased to offer to the readers of Frontiers in Oncology our Research Topic entitled, “Contemporary management of intracranial metastatic disease.” The development of intracranial metastatic disease (IMD) complicates the course of ~20% of patients with cancer, with the highest frequency of brain metastases arising in patients with melanoma, breast cancer, and lung cancer (, ). Modern therapeutic options available for treatment of IMD include surgical resection, stereotactic radiosurgery (SRS) and to an expanding degree, targeted, and immuno-therapies (). Despite improvements in patient survival with more aggressive treatment options as compared to the prior standard of palliative whole brain radiation, outcomes for patients who develop IMD remain dispiriting. There is need to celebrate our advances; but a major collaborative multidisciplinary effort is needed to push the field to achieve more meaningful survival benefits for our patients with IMD.
In this Research Topic, we have assembled work detailing the latest innovations in brain metastases imaging and management. Mehrabian et al. have reviewed work in the MR imaging field to identify advanced biomarkers that characterize the cellular, biophysical, micro-structural, and metabolic features of tumors to improve the management of brain metastases from early detection and diagnosis, to evaluating treatment response. Venur et al. review the contribution of genomic analysis of brain metastases to our understanding of variations in the driver mutations compared to the primary malignancy, and provide an in-depth review of the completed and ongoing clinical trials of drugs targeting the molecular pathways enriched in brain metastases. Kamath and Kumthekar review the biological rationale for systemic immunotherapy to treat CNS metastatic disease, and summarize existing clinical data on immune checkpoint inhibitors in this setting and ongoing clinical trials designed to study immune checkpoint inhibitor therapy in patients with IMD. Meng et al. review the prospect of focused ultrasound-mediated blood-brain barrier disruption to improve local drug delivery for patients with IMD. Minimally invasive surgical strategies using tubular retractors or laser interstitial thermal therapy (LITT) have been presented by Marenco-Hillembrand et al. and Salehi et al., respectively. Routman et al. review data to support the use of SRS as a neoadjuvant therapy to improve treatment contouring and diminish the risk of tumor cell dissemination during surgical resection and associated leptomeningeal spread. Masucci and Routman et al. detail the role of hyprofractionated SRS and post-operative SRS, respectively, for patients with IMD. Robin and Rusthoven and Schwendner et al. have reviewed efforts to minimize disease- and treatment-related cognitive and motor decline in patients with IMD. Vellayappan et al. explore the pathophysiology of radiation necrosis, risk factors for its development, and the strategies for its evaluation and management. Finally, Samuel Chao and colleagues define a treatment algorithm to guide treatment of patients with a limited number of brain metastases, while Roberge et al. describe plans for a prospective randomized control trial to define the role of SRS in patients with more severe burden of IMD.
In all of this, we owe thanks to our many colleagues who contributed to this Research Topic and offered us their time, intellect and energy. Many thanks as well to Jakob Mainusch and the editorial team at Frontiers. We thank Frontiers for appreciating the importance of this topic and for supporting the collection. We hope that you find it a valuable resource.
Author Contributions
SD wrote and edited the manuscript. AS edited the manuscript and provided guidance on its writing.
Conflict of Interest Statement
Driver Sunet
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Driver Sunet Windows
This is a Linux 2.6 driver for ISA, PC-104 and serial Indramat (aka BoschRexroth) CLC cards for SERCOS motion control. http://www.
- linuxclcdriver-2.0.gz
- linuxclc
- Freeware (Free)
- 55 Kb
- Linux
f you've tried to update your PC's drivers manually, you know how frustrating it can be. Each driver for your system comes from a different website; you need to make sure you're getting the right driver; you need to double-check compatibility with. ...
- Driver Robot
- Blitware Technology Inc.
- Shareware ($39.95)
- 4.3 Mb
- WinVista, WinVista x64, WinXP
Driver Update Robot is advanced automatic driver update & fix software with the world's largest and latest official driver database for your Windows PC. Its fast scan is guaranteed to detect 100% of your system's devices. ...
- setup.exe
- Repair-and-Secure
- Shareware ($29.95)
- 2.02 Mb
- Windows XP, Windows Vista, Windows7, Windows 2000, Windows 2003, Windows 98, Windows ME, Windows 95
Award-Winning Driver Turbo software was designed to discover a new level of performance technology, detecting all drivers on your PC in seconds and matching them with the latest, most up to date version available.
- DriverTurboSetup.exe
- Driver Turbo
- Shareware ($29.95)
- 184 Kb
- WinXP, WinVista, WinVista x64, Win7 x32, Win7 x64, Win2000, Windows2000, Windows Vista
UpdatesDriver updates all of your system drivers with just one click. With UpdatesDriver, you can easily get the latest official drivers for your machine. It supports millions of devices and the driver database is updated every day to ensure that. ...
- UpdatesDriver.exe
- CYQSoft Co., Ltd
- Shareware ($39.95)
- 1.5 Mb
- WinXP, WinVista, Win7 x32, Win2000, Windows2000, Windows2003, Windows Vista
DriverFinder finds device drivers for your PC in minutes. It offers fast driver downloads and even helps install drivers for you. Our non-stop growing driver database makes sure you find the drivers your PC needs. Easy-to-use. 100% safe & effective.
- DriverFinder_Setup.exe
- DeskToolsSoft
- Shareware ($29.95)
- 308 Kb
- WinXP, WinVista, WinVista x64, Win7 x32, Win7 x64, Windows Vista, Windows 8
Ever had painful headaches searching through the web trying to find the correct drivers for your newly formatted PC? 3DP Chip and 3DP Net are extremely useful freewares that will minimize your effort and time spent in finding the drivers for your PC. ...
- 3DP Net
- 3DPChip.com
- Freeware (Free)
- 31.3 Mb
- Windows2000, Windows2003, WinXP, Windows Vista, Windows 7
A set of tools for making the adminstration and support of large number of printers dramatically easier.Features: 64-Bit Support (CEPS Server) CEPS Client Supports VISTA Windows 7 Support is in progress HP Universal Driver Support - One Driver for all Printer Models.
- ceps-lpr-client-2.24.tar.gz
- ravina, saravanc, sseethap
- Shareware ($)
- 92 Kb
- Win All
Windows Vista printer supports easy jobs printing to multiple printers simultaneously. Printer drivers for windows Vista preview printing and include logos or background images stored in separate files. Print spooler software uses single,. ...
- Windows Vista PrinterSoftware
- Software Manuals
- Shareware ($120.00)
- 1.4 Mb
- Windows All
It captures what you see on screen and what you hear/say simultaneously, and saves them as compressed video file in real-time. It is usually used to create software demos, capture streaming videos and record game plays.
- screen-recorder-setup.exe
- GiliSoft International LLC.
- Shareware ($39.95)
- 440 Kb
- Win2000, Win7 x32, Win7 x64, WinVista, WinVista x64, WinXP, Win10
GiliSoft Video Recorder is a screen recording software for Windows. It captures what you see on screen and what you hear/say simultaneously, and saves them as compressed video file in real-time. It is usually used to create software demos, capture. ...
- screen-recorder32.exe
- GiliSoft International LLC.
- Shareware ($24.95)
- 5.51 Mb
- Win2000, Win7 x32, Win7 x64, WinVista, WinVista x64, WinXP
Download Free Antivirus protection for your Windows.UniversalPC Care provides you the best protection from unwanted junk in your desktop. 100 % Safe and Free. Repair all the corrupt & invalid registry entries to improve system response time and performance. View and manage all the startup items to improve system boot time & overall system performance.
- Universal PC Care
- COMPETENCE TECHNOLOGlES
- Shareware ($39.95)
- 6.74 Mb
- Win2000, WinXP, Win7 x32, Win7 x64, Windows 8, Windows 10, WinServer, WinOther, WinVista, WinVista x64
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